4-Methylmorpholine → HCID 86752866, compound

Participants

Reaction Steps

A mixture of 2-(4-biphenyl-4-yl-imidazol-1-yl)succinic acid 4-benzyl ester (450 mg, 1.05 mmol), (10S)-10-amino-9-oxo-1,8-diazatricyclo[10.6.1.013,18 ]nonadeca-12(19),13(18),14,16-tetraene (284 mg, 0.95 mmol), EDCI (302 mg, 1.5 mmol), HOBT (142 mg, 1.05 mmol), N-methylmorpholine (0.14 mL) and DMAP (50 mg) in DMF (10 mL) was stirred at room temperature overnight. The solution was diluted with 100 mL of EtOAc and washed with brine and saturated NaHCO3 and dried. The crude product obtained after removal of solvents was purified by column chromagraphy to give (3RS,10S)-3-(4-biphenyl-4-yl-imidazol-1-yl)-N-(9-oxo-1,8-diazatricyclo[10.6.1.013,18 ]nonadeca-12(19),13(18),14,16-tetraen-10-yl-succinamic acid benzyl ester.

Provenance & Evidence