HCID 86752866, compound → HCID 131720741, compound

Participants

Reaction Steps

A solution of (3RS,10S)-3-(4-biphenyl-4-yl-imidazol-1-yl)-N-(9-oxo-1,8-diaza-tricyclo[10.6.1.013,18 ]nonadeca-12(19),13(18),14,16-tetraen-10-yl-succinamic acid benzyl ester (190 mg) in THF/EtOH (5/1, 20 mL) was hydrogenated with 10% Pd/C (170 mg) for 8 hours until TLC indicated that the starting compound was consumed. The solution was filtered through a pad of Celite. The filtrate was evaporated and recrystallized (THF/EtOAc) to give 147 mg of (3RS,10S)-3-(4-biphenyl-4-yl-imidazol-1-yl)-N-(9-oxo-1,8-diaza-tricyclo[10.6.1.013,18 ]nonadeca-12(19),13(18),14,16-tetraen-10-yl-succinamic acid, melting point: 222°-226° C., MS: 604.2 (M+H)+.

Provenance & Evidence