反应详情

A solution of 4-methyl-2-methylenepentanoic acid (3.5 g) and O-benzylhydroxylamine were heated at 120° for 8 h. The reaction mixture was then partitioned between 50 mL of 1.0N NaOH and 50 mL of diethyl ether. The aqueous portion was separated, acidified to pH 3 with 10% HCl and washed with 50 mL of ether. Ion exchange chromatography (Dowex-50W) eluting with 20% pyridine/water gave 2-(benzyloxyaminomethyl)-4-methylpentanoic acid.

1. customThe reaction mixture was then partitioned between 50 mL of 1.0N NaOH and 50 mL of diethyl ether
2. customThe aqueous portion was separated
3. washwashed with 50 mL of ether
4. washIon exchange chromatography (Dowex-50W) eluting with 20% pyridine/water