m-Chloroperbenzoic acid → HCID 178526287, compound

Participants

Reaction Steps

N6 -Benzyladenosine (25 mg, 70 μmol) and m-chloroperbenzoic acid (38 mg, 220 μmol) were dissolved in 1 ml acetic acid. The resulting solution was stirred at room temperature for 2 days. The solvent was evaporated under a stream of nitrogen, and the residue was dissolved in a minimum of methanol and chromatographed on a silica plate (250μ) using acetonitrile:water, 4:1 (v/v). The UV absorbing band at Rf =0.53 was extracted with methanol to provide 7.3 mg (28% yield) of N6 -benzyladenosine-N1 -oxide. Mass and 1H-NMR spectra were consistent with the assigned structure.

Provenance & Evidence