HCID 23509063, compound → 2-amino-N-benzyl-3-methoxypropanamide

HRID 965203Notes

Reaction equation

HRID 965203 reaction equation
[CH2:1]([NH:8][C:9](=[O:25])[CH:10]([NH:14]C(OCC1C=CC=CC=1)=O)[CH2:11][O:12][CH3:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CO>[CH2:1]([NH:8][C:9](=[O:25])[CH:10]([NH2:14])[CH2:11][O:12][CH3:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 23509063HCID 23509063, compound

Product 1

HCID 98371812-amino-N-benzyl-3-methoxypropanamideYield 97%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 12 (122.8 mg, 0.36 mmol) in methanol (2.0 mL) was added 10% Pd--C (11 mg) and the mixture stirred at room temperature in the presence of H2 gas for 75 min. Celite was added to the reaction mixture and the catalyst was removed by filtration. The clear filtrate was evaporated in vacuo to give pure 13 as a clear viscous oil (72 mg, 97%): Rf 0.30 (5% MeOH/CHCl3).

Workup

  1. additionCelite was added to the reaction mixture
  2. customthe catalyst was removed by filtration
  3. customThe clear filtrate was evaporated in vacuo

Sources & evidence

ORD record
ord-d3ef1ecaa8764943bd7ba0efad2cb582
Source dataset
uspto-grants-1998_06
Patent number
US05773475

Reaction notes

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