Aluminium lithium hydride → HCID 54017568, compound

HRID 965209Notes

Reaction equation

HRID 965209 reaction equation
[H-].[H-].[H-].[H-].[Li+].[Al+3].[O:7]([C@@H:14]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH2:16][C@H:15]1[NH:23][C:24](OCC)=O)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>C(OCC)C>[O:7]([C@@H:14]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH2:16][C@H:15]1[NH:23][CH3:24])[C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 54287536HCID 54287536, compound

Product 1

HCID 54017568HCID 54017568, compoundYield 91.6%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

To a stirred suspension of LiAlH4 (0.22 g, 5.7 mmol) in dry diethyl ether (5 ml) under nitrogen was added a solution of (±) trans 1-(phenoxy)-2-ethoxycarbonylaminoindane (0.34 g, 1.14 mmol) in diethyl ether (10 ml). After stirring overnight at room temperature the reaction was worked up as described in Preparation 4 to give the title compound as a brown oil (0.25 g) which was used in the next stage without further purification.

Workup

  1. customas described in Preparation 4

Sources & evidence

ORD record
ord-4fb90ad18d7b41d4b2cdb67b238f76d5
Source dataset
uspto-grants-1998_06
Patent number
US05773463

Reaction notes

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