Triethylamine → HCID 53809650, compound

Participants

Reaction Steps

A solution of (±) trans 1-(2-benzylanilino)-2-methylaminoindane (Example 2)(0.66 g, 2.0 mmol) in dry diethyl ether (25 ml) was treated with triethylamine (0.55 ml, 4.0 mmol) and ethyl chloroformate (0.21 ml, 2.2 mmol). After stirring at room temperature for 1 h, the reaction was concentrated in vacuo and the residue was partitioned between chloroform (25 ml) and water (25 ml). The organic layer was washed with water (3×25 ml) followed by brine (25 ml), and then concentrated in vacuo to give a brown oil (0.73 g) which crystallised on cooling and was used in the next stage without purification.

Provenance & Evidence