反应详情

To a suspension of LiAlH4 (0.34 g, 9.05 mmol) in dry diethyl ether under nitrogen was added a solution of (±) trans 1-(3,4-dichlorophenylthio)-2-ethoxycarbonylaminoindane (0.69 g, 1.81 mmol) in diethyl ether. After stirring at room temperature overnight, the reaction was worked up as described for Example 2, and then purified on a silica gel column using 1% ethanol in chloroform as eluant. The resulting oil (0.26 g) was extracted into n-pentane and treated with ethereal hydrogen chloride to give the title compound as a colourless solid, m.p. 143°-144° C. (from methanol/diethyl ether).

1. custompurified on a silica gel column
2. extractionThe resulting oil (0.26 g) was extracted into n-pentane
3. additiontreated with ethereal hydrogen chloride