Ethanol → (+/-)cis-1-(2-Benzylphenoxy)-2-dimethylaminoindane Hydrochloride

Participants

Reaction Steps

The title compound was prepared in a similar manner to Example 12 from LiAlH4 (401 mg, 10.6 mmol), cis-1-(2-benzylphenoxy)-2-(N-methyl-N-tert-butoxycarbonylamino)indane (453 mg, 1.06 mmol) and tetrahydrofuran (50 ml). After a reaction time of 3 h the reaction was worked up as previously described and subjected to column chromatography on silica gel eluting with 5% ethanol in chloroform to afford a pale green oil (331 mg) which was converted to the HCl salt and crystallised to afford the title compound as a white solid. m.p. 222°-225° C. (from methanol-diethyl ether).

Provenance & Evidence