Ethanol → (+/-)cis-1-(4-Benzyloxyphenoxy)-2-Methylaminoindane Hydrochloride

Participants

Reaction Steps

The title compound was prepared in a similar manner to Example 12 from LiAlH4 (760 mg, 20 mmol), (±) cis-1-(4-benzyloxyphenoxy)-2-tert-butoxycarbonylaminoindane (1 g, 2.3 mmol) and tetrahydrofuran (50 ml). After a reaction time of 4 h the reaction was worked up as previously described and subjected to column chromatography on silica gel eluting with 5% ethanol in chloroform to afford a pale yellow oil (765 mg) which was converted to the HCl salt and crystallised to afford the title compound as a white solid. m.p. >195° C. dec.(from methanol-diethyl ether).

Provenance & Evidence