Ethanol → HCID 18661289, compound

Participants

Reaction Steps

The title compound was prepared in a similar manner to Example 12 from LiAlH4 (769 mg, 20.2 mmol), cis-1-(4-benzyloxyphenoxy)-2-(N-methyl-N-tert-butoxycarbonylamino)indane (900 mg, 2.02 mmol) and tetrahydrofuran (50 ml). After a reaction time of 3 hours the reaction was worked up as previously described and subjected to column chromatography on silica gel eluting with 5% ethanol in chloroform to afford a pale green oil (640 mg) which was converted to the HCl salt and crystallised to afford the title compound as a white solid. m.p. 215°-216° C. dec. (from methanol-diethyl ether).

Provenance & Evidence