Ethanol → (+/-)trans-1-(4-Benzyloxyphenoxy)-2-methylaminoindane Hydrochloride

Participants

Reaction Steps

The title compound was prepared in a similar manner to Example 12 from LiAlH4 (190 mg, 5 mmol), trans-1-(4-benzyloxyphenoxy)-2-ethoxycarbonylaminoindane (750 mg, 1.7 mmol) and tetrahydrofuran (50 ml). After a reaction time of 18 h at room temperature and a further hour at reflux, the reaction was worked up as previously described and subjected to column chromatography on silica gel eluting with 2% ethanol in chloroform to afford a pale yellow oil (290 mg) which was converted to the HCl salt and crystallised to afford the title compound as a white solid. m.p. 185°-187° C. (from methanol-diethyl ether).

Provenance & Evidence