Ethanol → (+/-)cis-1-(4-Benzylphenoxy)-2-methylaminoindane Hydrochloride

Participants

Reaction Steps

The title compound was prepared in a similar manner to Example 12 from LiAlH4 (320 mg, 8.4 mmol), cis-1-(4-benzylphenoxy)-2-tert-butoxycarbonylaminoindane (700 mg, 1.7 mmol) and tetrahydrofuran (40 ml). After a reaction time of 2.5 h the reaction was worked up as previously described and subjected to column chromatography on silica gel eluting with 2% ethanol in chloroform to afford a colourless oil (438 mg) which was converted to the HCl salt and crystallised to afford the title compound as a white solid. m.p. 222° C. dec. (from methanol-diethyl ether).

Provenance & Evidence