Ethanol → (+/-) cis-1-Phenoxy-2-methylaminoindane Hydrochloride

Participants

Reaction Steps

The title compound was prepared in a similar manner to Example 12 from LiAlH4 (250 mg, 6.5 mmol), (±) cis-1-phenoxy-2-tert-butoxycarbonylaminoindane (425 mg, 1.3 mmol) and tetrahydrofuran (30 ml). After a reaction time of 2 h the reaction was worked up as previously described and subjected to column chromatography on silica gel eluting with 5% ethanol in chloroform to afford a colourless oil (290 mg) which was converted to the HCl salt and crystallised to afford the title compound as a white solid. m.p. >215° C. dec. (from methanol-diethyl ether).

Provenance & Evidence