Acetone → HCID 54411918, compound

Participants

Reaction Steps

The title compound was prepared in a similar manner to Example 31 from (±) cis-2-amino-1-[4-(4-fluorophenoxy)phenoxy]indane (70 mg, 0.2 mmol), sodium cyanoborohydride (25 mg, 0.4 mmol), acetone (0.29 ml, 4 mmol) and acetonitrile (10 ml). After subjecting the crude product to column chromatography on silica gel eluting with 5% ethanol in chloroform, residual boron impurities were removed by dissolving the product in hexanes and filtering. Removal of the hexanes in vacuo afforded the title compound (40 mg) as a colourless oil.

Provenance & Evidence