Lithium hydroxide, monohydrate → HCID 131720115, compound

Participants

Reaction Conditions

Reaction Steps

0.3 g of LiOH.H2O are dissolved in 1.5 ml of water and the solution is diluted with MeOH to a total volume of 10 ml. This solution, pre-cooled to 0°-50° C., is added to a solution of 1 g of methyl 5-BOC-amino-2-hydroxy-2-methoxycarbonyl-pentanoate in 10 ml of MeOH, cooled at 0° C. The mixture is kept for 24 h at 0°-5° C., under mild stirring. A white crystalline precipitate separates, which is filtered, washed with MeOH and dried to obtain 0.86 g of 5-BOC-amino-2-hydroxy-2-carboxy-pentanoic acid lithium salt (m.p.>300° C.) TLC (3:1:1 nBuOH--AcOH--H2O) Rf=0.35 I.R.: (C=O 1700 cm-1) (COO--1595 cm-1, 1620 cm-1) (--OH, --NH--3500-3300 cm-1).

Provenance & Evidence