2-(2-Chloroethoxy)tetrahydro-2H-pyran → 1-(2-Hydroxyethyl)-3-methylthio-3-phenylmethyl-1,3-dihydro-2H-indol-2-one

HRID 965287Notes

Reaction equation

HRID 965287 reaction equation
[CH3:1][S:2][C:3]1([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[NH:5][C:4]1=[O:12].Cl[CH2:21][CH2:22][O:23]C1CCCCO1>>[OH:23][CH2:22][CH2:21][N:5]1[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:3]([S:2][CH3:1])([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:4]1=[O:12]

Participants

3

Reactant 2

HCID 2549512-(2-Chloroethoxy)tetrahydro-2H-pyranHCID 190750183-methylthio-3-phenylmethyl-1,3-dihydro-2H-indol-2-one

Product 1

HCID 190750041-(2-Hydroxyethyl)-3-methylthio-3-phenylmethyl-1,3-dihydro-2H-indol-2-one

Procedure

Prepared from 3-methylthio-3-phenylmethyl-1,3-dihydro-2H-indol-2-one and 2-(2-chloroethoxy)tetrahydro-2H-pyran as described in Example 1.

Sources & evidence

ORD record
ord-153e8cf776dd4ac1a534946fd8d433e1
Source dataset
uspto-grants-1998_06
Patent number
US05773448

Reaction notes

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