Oxindole → 3-(1-Methylethyl)-3-methylthio-1,3-dihydro-2H-indol-2-one

HRID 965291Notes

Reaction equation

HRID 965291 reaction equation
[CH3:1][CH:2]([CH:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][C:5]1=[O:13])[CH3:3].N1C2C(=CC=CC=2)CC1=O.[CH3:24][S:25]C1(CC2C=CC=CC=2)C2C(=CC=CC=2)NC1=O>CC(C)=O>[CH3:3][CH:2]([C:4]1([S:25][CH3:24])[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][C:5]1=[O:13])[CH3:1]

Participants

5

Reactant 3

HCID 321710OxindoleHCID 44614893-(propan-2-yl)-2,3-dihydro-1H-indol-2-oneHCID 190750183-methylthio-3-phenylmethyl-1,3-dihydro-2H-indol-2-one

Product 1

HCID 190750013-(1-Methylethyl)-3-methylthio-1,3-dihydro-2H-indol-2-one

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Prepared from 3-(1-methylethyl)-1,3-dihydro-2H-indol-2-one (prepared from 1,3-dihydro-2H-indol-2-one and acetone by the method of Daisley and Walker, J. Chem. Soc. (C) (1971) page 1373) by the method described above for 3-methylthio-3-phenylmethyl-1,3-dihydro-2H-indol-2-one.

Sources & evidence

ORD record
ord-7024efe01b14459b93e381d90eea42ab
Source dataset
uspto-grants-1998_06
Patent number
US05773448

Reaction notes

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