2-(2-Chloroethoxy)tetrahydro-2H-pyran → 3,3-Dimethyl-1-(2-hydroxyethyl)-5-methanesulfonyl-1,3-dihydro-2H-indol-2-one

HRID 965296Notes

Reaction equation

HRID 965296 reaction equation
[CH3:1][C:2]1([CH3:16])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([S:11]([CH3:14])(=[O:13])=[O:12])[CH:9]=2)[NH:4][C:3]1=[O:15].Cl[CH2:18][CH2:19][O:20]C1CCCCO1>>[CH3:1][C:2]1([CH3:16])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([S:11]([CH3:14])(=[O:13])=[O:12])[CH:9]=2)[N:4]([CH2:18][CH2:19][OH:20])[C:3]1=[O:15]

Participants

3

Reactant 2

HCID 2549512-(2-Chloroethoxy)tetrahydro-2H-pyranHCID 225957463,3-Dimethyl-5-(methylsulfonyl)indolin-2-one

Product 1

HCID 190750193,3-Dimethyl-1-(2-hydroxyethyl)-5-methanesulfonyl-1,3-dihydro-2H-indol-2-one

Procedure

Prepared from 3,3-dimethyl-5-methanesulfonyl-1,3-dihydro-2H-indol-2-one and 2-(2-chloroethoxy)tetrahydro-2H-pyran.

Sources & evidence

ORD record
ord-3b220d50689d4739ae2021db8fbf429a
Source dataset
uspto-grants-1998_06
Patent number
US05773448

Reaction notes

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