Chloroform → HCID 86752880, compound

Participants

Reaction Steps

A solution of 1-(2-chloroethyl)-5-fluoro-1H-indole-2,3-dione (2.27 g), propanedithiol (1.1 ml) in chloroform was added dropwise to a stirred solution of boron trifluoride etherate (1.2 ml) in acetic acid (2.2 ml) and chloroform (10 ml) which was maintained at a gentle reflux throughout the addition. After 1.5 h reaction time the mixture was cooled, washed with water and sodium hydrogen carbonate solution, dried (MgSO4) and filtered through a pad of flash silica using chloroform as eluent. The combined fractions were evaporated under reduced pressure and triturated with ether to give 1-(2-chloroethyl)-1,3-dihydro-5-fluoro-2-oxo-2H-indole-3-spiro-2'-1,3-dithiane.

Provenance & Evidence