HCID 86752880, compound → HCID 22116121, compound

Participants

Reaction Steps

1-(2-chloroethyl)-1,3-dihydro-5-fluoro-2-oxo-2H-indole-3-spiro-2'-1,3-dithiane (2.08 g) was dissolved in a mixture of ethanol (30 ml) and tetrahydrofuran (20 ml). Raney nickel was added and the mixture was heated under reflux with vigorous stirring for 3 hours. The cooled solution was filtered, evaporated under reduced pressure and triturated with ether to give 1-(2-Chloroethyl)-5-fluoro-1,3-dihydro-2H-indole-2-one as a white solid.

Provenance & Evidence