HCID 54034076, compound → 2-(Thymin-1-ylcarbonylamino)-5-(t-butyloxycarbonyl-amino)pentanoic acid

HRID 965322Notes

Reaction equation

HRID 965322 reaction equation
C([O:3][C:4](=[O:29])[CH:5]([NH:17][C:18]([N:20]1[CH:28]=[C:26]([CH3:27])[C:24](=[O:25])[NH:23][C:21]1=[O:22])=[O:19])[CH2:6][CH2:7][CH2:8][NH:9][C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])C>C(O)C.[OH-].[Na+]>[N:20]1([C:18]([NH:17][CH:5]([CH2:6][CH2:7][CH2:8][NH:9][C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[C:4]([OH:29])=[O:3])=[O:19])[CH:28]=[C:26]([CH3:27])[C:24](=[O:25])[NH:23][C:21]1=[O:22]

Participants

4

Reactant 1

HCID 54034076HCID 54034076, compound

Product 1

HCID 190762582-(Thymin-1-ylcarbonylamino)-5-(t-butyloxycarbonyl-amino)pentanoic acid

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

The product from Example 11, 15, is dissolved in ethanol (500 mL) and to this added 2M sodium hydroxide (50 mL) and the reaction stirred for 12 hours. The reaction is neutralized with 2M HC1 solution (50 mL) and evaporated to a small volume. This residue is diluted with water (250 mL) and extracted with dichloromethane (4×100 mL), dried, filtered, and evaporated to give a solid.

Workup

  1. customevaporated to a small volume
  2. additionThis residue is diluted with water (250 mL)
  3. extractionextracted with dichloromethane (4×100 mL)
  4. customdried
  5. filtrationfiltered
  6. customevaporated
  7. customto give a solid

Sources & evidence

ORD record
ord-63e2de4bc3bf41d8b7074817254b394f
Source dataset
uspto-grants-1998_06
Patent number
US05773571

Reaction notes

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