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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 965375Generated: October 30, 2026

Chloride → 1-(3,5-di-O-acetyl-2-deoxy-2-fluoro-beta-D-ribofuranosyl)-5-(dimethylaminomethyleneamino)imidazole-4-carbonyl chloride

https://huagongshe.com/reaction/965375

Reaction equation

Participants

RoleNameHCIDCharge
ReactantChlorideHCID 312—
Reactant5-amino-1-(3,5-di-O-acetyl-2-deoxy-2-fluoro-beta-D-ribofuranosyl)imidazole-4-carboxylic acidHCID 15858364—
SolventTetrahydrofuranHCID 8028—
Product1-(3,5-di-O-acetyl-2-deoxy-2-fluoro-beta-D-ribofuranosyl)-5-(dimethylaminomethyleneamino)imidazole-4-carbonyl chlorideHCID 54164098—

Reaction Steps

In step 12, compound (18) is dissolved in tetrahydrofuran and reacted with N,N-dimethylchloroforminium chloride under ice-cooling, whereby 1-(3,5-di-O-acetyl-2-deoxy-2-fluoro-β-D-ribofuranosyl)-5-(dimethylaminomethyleneamino)imidazole-4-carbonyl chloride [compound (19)] is produced.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05773607
Source datasetuspto-grants-1998_06
ORD IDord-9c50216a68a34a87a111e97c8883e573
Source noteuspto-grants-1998_06