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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 965378Generated: October 30, 2026

Sodium Azide → 1-(3,5-di-O-acetyl-2-deoxy-2-fluoro-beta-D-ribofuranosyl)-4-azidoacetyl-5-(dimethylaminomethyleneamino)imidazole

https://huagongshe.com/reaction/965378

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium AzideHCID 33557—
Reactant1-(3,5-di-O-acetyl-2-deoxy-2-fluoro-beta-D-ribofuranosyl)-4-chloroacetyl-5-(dimethylaminomethyleneamino)imidazoleHCID 53871728—
SolventDimethylformamideHCID 6228—
Product1-(3,5-di-O-acetyl-2-deoxy-2-fluoro-beta-D-ribofuranosyl)-4-azidoacetyl-5-(dimethylaminomethyleneamino)imidazoleHCID 54278308—

Reaction Steps

In step 15, compound (21) is reacted with sodium azide in N,N-dimethylformamide at room temperature for converting the chloro group of compound (21) into azido group, whereby 1-(3,5-di-O-acetyl-2-deoxy-2-fluoro-β-D-ribofuranosyl)-4-azidoacetyl-5-(dimethylaminomethyleneamino)imidazole [compound (22)] is produced.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05773607
Source datasetuspto-grants-1998_06
ORD IDord-76042eb922474d2eb28ae733390339cf
Source noteuspto-grants-1998_06