huagongshe.com
HRID965396

反应详情

EQUATION

反应方程式

HRID 965396 的结构方程式

REACTANTS

反应物

2
结构：O=C=O
HCID280

Carbon dioxide

CO2

结构：CN(C)C=Nc1c(C(=O)CN)ncn1[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1F
HCID53794521

未命名化合物

PRODUCTS

生成物

1
结构：O=C1CNC=Nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1F
HCID178516779

未命名化合物

收率 30.3%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CO
溶剂HCID887

Methanol

CH4O

结构：C[O-].[Na+]
溶剂HCID10942334

Methanol, sodium salt

CH3NaO

PROCEDURE

实验过程

Compound (41) (18 mg) obtained in item (8) above was dissolved in a 0.1M sodium methylate solution (0.72 ml) in methanol, and the resultant solution was allowed to stand at room temperature overnight. The reaction solution as formed was neutralized with addition of dry ice and then concentrated to leave a residue. The residue was purified by silica gel column chromatography (developer: the lower layer of water-methanol-chloroform, 1:2:4), affording the titled compound (42) (4.7 mg) as a colorless solid. Yield: 30%.

WORKUP

后处理

  1. customThe reaction solution as formed
  2. concentrationconcentrated
  3. customto leave a residue
  4. customThe residue was purified by silica gel column chromatography (developer