HCID 54485346, compound → HCID 18661322, compound

HRID 965397Notes

Reaction equation

HRID 965397 reaction equation
[F:1][C@H:2]1[C@H:6]([OH:7])[C@@H:5]([CH2:8][OH:9])[O:4][CH:3]1[N:10]=[N+]=[N-].[H][H]>O1CCOCC1.[Pd]>[F:1][C@H:2]1[C@H:6]([OH:7])[C@@H:5]([CH2:8][OH:9])[O:4][CH:3]1[NH2:10]

Participants

5

Reactant 2

HCID 54485346HCID 54485346, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 18661322HCID 18661322, compoundYield 92%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 312751,4-DioxaneSolvent

Procedure

Compound (45) (65.0 mg) was dissolved in dioxane (2 ml) and the solution was catalytically reduced by blowing hydrogen therein in the presence of palladium black as catalyst at room temperature for 1 hour. The resulting reaction solution was filtered and the filtrate was concentrated to afford the titled compound (46) (51.0 mg) as a colorless solid. Yield: 92%.

Workup

  1. customThe resulting reaction solution
  2. filtrationwas filtered
  3. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-dfd6b3d6ace042489570a4502e53ca58
Source dataset
uspto-grants-1998_06
Patent number
US05773607

Reaction notes

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