3-Hydroxybenzaldehyde → 3-Isopropoxybenzaldehyde

Participants

Reaction Conditions

Reaction Steps

50 g of 3-hydroxybenzaldehyde are dissolved, under nitrogen, in 250 ml of DMF. 60 g of K2CO3 and then 60 ml of 2-iodopropane are added and the reaction mixture is heated for 18 hours at 50° C. and poured into 2.5 liters of water. Extraction is carried out with ethyl ether and the ether phase is washed with a dilute solution of NaOH, dried over MgSO4 and concentrated under vacuum to give 53.5 g of an oil.

Provenance & Evidence