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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 965404Generated: October 30, 2026

Thionyl Chloride → 1,2-Benzisothiazol-3(2H)-one

https://huagongshe.com/reaction/965404

Reaction equation

Participants

RoleNameHCIDCharge
ReactantThionyl ChlorideHCID 24386—
ReactantMetaperiodic acidHCID 65185—
ReactantHCID 12242117HCID 12242117—
Product1,2-Benzisothiazol-3(2H)-oneHCID 17520—

Reaction Steps

In this method, 2-(methylthio)benzamide is produced from 2-(methylthio)benzoyl chloride; oxidized with periodic acid to 2-(methylsulfinyl)benzamide; and cyclized in the presence of thionyl chloride to yield a 1,2-benzisothiazol-3-one. ##STR1## (B) Org. Prep. Proced. Int., 15, 315-319(1983)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05773626
Source datasetuspto-grants-1998_06
ORD IDord-3dc21b545d6c40f7bca2193a2c84fd84
Source noteuspto-grants-1998_06