4-Toluenesulfonyl chloride → HCID 86752876, compound

Participants

Reaction Steps

Triethylamine (3 ml, 2.18 g, 0.022 mol) was added to acetamide oxime (1.5 g, 0.02 mol) in tetrahydrofuran (THF) (45 ml). To the mixture, p-toluenesulfonyl chloride (Tosylchloride, TsCl) (4.2 g, 0.022 mol) was added in small portions (generating heat intensively). The mixture was allowed to react at room temperature for 45 mins. and the precipitates were collected by filtration. THF was distilled off under reduced pressure, and water was added to the resultant residue. The residue was extracted with ethyl acetate, and the organic layer was washed with water and dried over sodium sulfate. The ethyl acetate was distilled off under reduced pressure, and isopropyl ether was added to the residue to separate crystals. The crystals were filtered off is and dried to give acetamide-oxime-tosylate (3.2 g, yield; 69.2%).

Provenance & Evidence