Hydrochloric Acid → HCID 136047381, compound

Participants

Reaction Steps

Sodium hydroxide (12.9 g, 321.1 mmol) in water (268 ml) was added to ethyl 2-fluoromethoxyimino-cyanoacetate (46.6 g, 267.6 mmol) under ice-cooling, and the mixture was stirred at room temperature for 3 hrs. To the reaction mixture, hydroxylamine hydrochloride (20.5 g, 294.4 mmol) and then potassium carbonate (16.7 g, 120.4 mmol) were added under ice-cooling, and the mixture was stirred at a room temperature overnight and then concentrated hydrochloric acid (22.3 ml, 267.6 mmol) was added (pH 2). The mixture was concentrated at an internal temperature of 30° C., and then cooled when crystals were separated. The crystals were filtered off and dried to give 2-carboxy-2-fluoromethoxyimino-acetamidoxime (21.3 g, yield: 44.6%).

Provenance & Evidence