Formic Acid → HCID 54364803, compound

Participants

Reaction Steps

A solution of methyl 2-fluoromethoxyimino-2-(5-amino-1,2,4-thiadiazole-3-yl)-acetate (anti-isomer) (1.17 g, 5 mmol) in 99% formic acid (2.34 g, 51 mmol) was reacted at 35° C. for 90 hrs. The reaction mixture was cooled to below 10° C. to separate crystals, which were collected by filtration, washed with methanol and dried to give methyl 2-fluoromethoxyimino-2-(5-formamido-1,2,4-thiadiazole-3-yl)-acetate (syn-isomer) (434 mg). The crystals thereof (100 mg) were further obtained from the mother liquor. (Yield: 39.6%).

Provenance & Evidence