Formic Acid → HCID 57247295, compound

Participants

Reaction Steps

To a suspension of 2-fluoromethoxyimino-2-(5-amino-1,2,4-thiadiazole-3-yl) acetamide (anti-isomer) (3.51 g, 16 mmol) in 99% formic acid (14.73 g, 320 mmol), acetic anhydride (4.90 g, 48 mmol) was added, and the mixture was reacted at 40° C. for 50 hrs, and then cooled to below 10° C. to separate crystals. The crystals were collected by filtration and washed with cold methanol (10 ml) on Nutsche. The crystals in DMF (16 ml) were heated to dissolve and the resulting solution was dispersed in methanol (32 ml), and then cooled, filtered and dried to give 2-fluoromethoxyimino-2-(5-formamido-1,2,4-thiadiazole-3-yl) acetamide (syn-isomer) (2.43 g, yield: 61.4%). The content obtained by HPLC: 99.0% (anti-isomer: 0.2%).

Provenance & Evidence