Ammonia → HCID 11052302, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5 g of racemic ethyl 2-(4-chloro-phenyl)-propionate and 50 ml of tert-butanol is added to an autoclave at room temperature and treated with 1 g of lipase from Candida antarctica (Novozym 435, activity 7000 PLU/g). The mixture is then cooled to -50° C. and 0.5 g of ammonia is condensed into the reaction mixture. The pressure vessel is sealed, warmed to 50° C. and the mixture is allowed to react for 24 hours with stirring. It is then worked up in the manner described above. 1.78 g (42.8% of theory) of (R)-2-(4-chloro-phenyl)-propionamide having an ee value of 99.1% are obtained.

Provenance & Evidence