Ammonia → 14182-57-1

Participants

Reaction Steps

A mixture of 1.6 g of ethyl 2-phenyl-propionate and 18 ml of tert-butanol is treated at 50° C. with stirring with 0.35 g of lipase from Candida antarctica (Novozym 435, activity 7000 PLU/g). Ammonia is then passed into the reaction mixture with stirring at 50° to 53° C. until it is saturated. The mixture is stirred at 50° to 53° C. for a further 8 hours and during the course of this a slow stream of ammonia is continuously passed through the apparatus. The mixture is then worked up in the manner indicated in Example 1. 0.6 g (90% of theory, conversion 46 area per cent GC) of (R)-2-phenyl-propionamide having an ee value of >98% is obtained.

Provenance & Evidence