Hydrochloric Acid → 2,6-Dichloro-2',3',4'-trimethoxy-6'-methyl-benzophenone

Participants

Reaction Conditions

Reaction Steps

A mixture of 3,4,5-trimethoxytoluene (9.11 g; 50 mmol), octane (25 ml) and iron(III)chloride (50 mg) is stirred at 105° C., and percolating nitrogene 2,6-dichlorobenzoylchloride (12.04 g; 57.5 mmol) is added dropwise within 15 minutes. The mixture is kept at 105° C. and stirred for another 15 minutes. After cooling to 50° C. ethylacetate (50 ml) is added, the mixture shaken twice with 2N hydrochloric acid, once with water and dried. The ethylacetate is evaporated (70° C.) and the liquid cooled with stirring. At 50° C. petrolether (50 ml) is added. The white crystalls formed are sucked off, washed with petrolether and dried. Yield 12.55 g (70.7%), mp. 92° C.

Provenance & Evidence