참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Toluene | HCID 1140 | — |
| 반응물 | 3-Methoxytoluene | HCID 7530 | — |
| 반응물 | 2,6-Dichlorobenzoyl chloride | HCID 78392 | — |
| 촉매 | Iron chloride (FeCl3) | HCID 24380 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2,6-Dichloro-4'-methoxy-2'-methyl-benzophenone | HCID 54505258 | — |
반응 단계
A mixture of 2,6-dichlorobenzoylchloride (5.24 g; 25 mmol), 3-methylanisole (2.44 g; 20 mmol) and iron(III)chloride (20 mg) is heated to 100° C. for 45 minutes with stirring. After cooling, toluene is added, the mixture is shaken with water, the organic phase is dried and the solvent is evaporated. The reaction product is purified chromatograpically (flash column with 70 g of silicagel; elution with petrolether/toluene changing from 75:25 to 40:60 (v/v)). After evaporation the residue from the main fraction is treated with petrolether to give white crystalls (1.33 g; 22.5% y); mp. 89° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05773663 |
|---|
| 출처 데이터셋 | uspto-grants-1998_06 |
|---|
| ORD ID | ord-8c732aa0e59449639e94b72171f7f0af |
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| 출처 메모 | uspto-grants-1998_06 |
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