5-ethoxy-2,3-dihydro-1H-indole-2,3-dione → 3-(2-Chlorophenyl)-5-ethoxy-1,3-dihydro-3-hydroxyindol-2-one

HRID 965531Notes

Reaction equation

HRID 965531 reaction equation
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][C:8](=[O:13])[C:7]2=[O:14])[CH3:2].[Cl:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[Mg]Br>>[Cl:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[C:7]1([OH:14])[C:6]2[C:10](=[CH:11][CH:12]=[C:4]([O:3][CH2:1][CH3:2])[CH:5]=2)[NH:9][C:8]1=[O:13]

Participants

3

Reactant 2

HCID 167947905-ethoxy-2,3-dihydro-1H-indole-2,3-dioneHCID 178478041HCID 178478041, compound

Product 1

HCID 190766263-(2-Chlorophenyl)-5-ethoxy-1,3-dihydro-3-hydroxyindol-2-one

Procedure

This compound is prepared according to the procedure described in Preparation 6 from 5-ethoxyisatin and 2-chlorophenylmagnesium bromide (prepared according to P. G. Gassman in J. Am. Chem. Soc., 1974, 9, 5512).

Workup

  1. customThis compound is prepared

Sources & evidence

ORD record
ord-efe257dbdd5c45de86ebbe9677f4870a
Source dataset
uspto-grants-1998_06
Patent number
US05773612

Reaction notes

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