Acetyl chloride → 3-Acetamido-3-(2-chlorophenyl)-5-ethoxy-1-[4-(N',N'-diethylureido)benzenesulfonyl]-1,3-dihydroindol-2-one

HRID 965568Notes

Reaction equation

HRID 965568 reaction equation
[NH2:1][C:2]1([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=2[Cl:38])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([O:11][CH2:12][CH3:13])[CH:9]=2)[N:4]([S:14]([C:17]2[CH:22]=[CH:21][C:20]([NH:23][C:24]([N:26]([CH2:29][CH3:30])[CH2:27][CH3:28])=[O:25])=[CH:19][CH:18]=2)(=[O:16])=[O:15])[C:3]1=[O:31].[C:39](Cl)(=[O:41])[CH3:40]>>[C:39]([NH:1][C:2]1([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=2[Cl:38])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([O:11][CH2:12][CH3:13])[CH:9]=2)[N:4]([S:14]([C:17]2[CH:18]=[CH:19][C:20]([NH:23][C:24]([N:26]([CH2:29][CH3:30])[CH2:27][CH3:28])=[O:25])=[CH:21][CH:22]=2)(=[O:16])=[O:15])[C:3]1=[O:31])(=[O:41])[CH3:40]

Participants

3

Reactant 2

HCID 6367Acetyl chlorideHCID 190764053-Amino-3-(2-chlorophenyl)-5-ethoxy-1-[4-(N',N'-diethylureido)benzenesulfonyl]-1,3-dihydroindol-2-one

Product 1

HCID 190763923-Acetamido-3-(2-chlorophenyl)-5-ethoxy-1-[4-(N',N'-diethylureido)benzenesulfonyl]-1,3-dihydroindol-2-one

Procedure

This compound is prepared according to the procedure described in EXAMPLE 2 from the compound obtained in EXAMPLE 87 and acetyl chloride. Crystallization from a DCM/iso ether mixture gives the expected product, which crystallizes with 0.25 mol of iso ether.

Workup

  1. customThis compound is prepared
  2. customCrystallization from a DCM/iso ether mixture

Sources & evidence

ORD record
ord-e4773f3df7ad4aafb473219b95bc2fea
Source dataset
uspto-grants-1998_06
Patent number
US05773612

Reaction notes

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