2,4-Dimethoxybenzenesulfonyl chloride → HCID 19076595, compound

HRID 965585Notes

Reaction equation

HRID 965585 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([F:11])[CH:10]=1)[NH:7][C:6](=[O:12])[C:5]2([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[Cl:21])[NH:13][CH3:14].[CH3:22][O:23][C:24]1[CH:29]=[C:28]([O:30][CH3:31])[CH:27]=[CH:26][C:25]=1[S:32](Cl)(=[O:34])=[O:33]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([F:11])[CH:10]=1)[N:7]([S:32]([C:25]1[CH:26]=[CH:27][C:28]([O:30][CH3:31])=[CH:29][C:24]=1[O:23][CH3:22])(=[O:34])=[O:33])[C:6](=[O:12])[C:5]2([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[Cl:21])[NH:13][CH3:14]

Participants

3

Reactant 2

HCID 27346262,4-Dimethoxybenzenesulfonyl chlorideHCID 19076483HCID 19076483, compound

Product 1

HCID 19076595HCID 19076595, compoundYield 20.5%

Procedure

This compound is prepared according to the procedure described in EXAMPLE 1 from 0.25 g of 5-chloro-3-(2-chlorophenyl)-7-fluoro-1,3-dihydro-3-(methylamino)indol-2-one and 0.165 g of 2,4-dimethoxybenzenesulfonyl chloride. 0.075 g of the expected product is obtained after crystallization and recrystallization from a DCM/iso ether mixture. M.p.=183°-185° C.

Workup

  1. customThis compound is prepared

Sources & evidence

ORD record
ord-95f0579687214d4d8c5d18e1b869314e
Source dataset
uspto-grants-1998_06
Patent number
US05773612

Reaction notes

Loading…