HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-Acetyl-2,3-dihydro-1H-indole-5-sulfonyl chloride → 1-[(1-Acetylindolin-5-yl)sulfonyl]-5-chloro-3-(2-chlorophenyl)-1,3-dihydro-3-[(3-methoxypropyl)amino]indol-2-one hemihydrate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-Acetyl-2,3-dihydro-1H-indole-5-sulfonyl chloride | HCID 14024596 | — |
| Edukt | 5-Chloro-3-(2-chlorophenyl)-1,3-dihydro-3-[(3-methoxypropyl)amino]indol-2-one | HCID 19076606 | — |
| Produkt | 1-[(1-Acetylindolin-5-yl)sulfonyl]-5-chloro-3-(2-chlorophenyl)-1,3-dihydro-3-[(3-methoxypropyl)amino]indol-2-one hemihydrate | HCID 88358341 | 84,5% |
Reaktionsschritte
This compound is prepared according to the procedure described in EXAMPLE 222 from 1 g of 5-chloro-3-(2-chlorophenyl)-1,3-dihydro-3-[(3-methoxypropyl)amino]indol-2-one and 0.711 g of 1-acetylindoline-5-sulfonyl chloride. 0.921 g of the expected product is obtained after crystallization from a DCM/iso ether mixture. M.p=158°-162° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05773612 |
| Quelldatensatz | uspto-grants-1998_06 |
| ORD ID | ord-7dcaf9e38a46440ab878c55a5f013fab |
| Quellennotiz | uspto-grants-1998_06 |