Boron tribromide → HCID 22312839, compound

Participants

Reaction Steps

A solution of 7-(4-methoxyphenoxy)-2H-1,4-benzoxazin-3(4H)-one (120 mg; 0.44 mmol) in CH2Cl2 (1 ml) was treated with BBr3 (332 mg; 1.33 mmol). The mixture was stirred at room temperature for 3 hours. After evaporation to dryness the residue was taken up in EtOAc and water. The organic phase was washed with brine and dried over MgSO4. The residue (110 mg) was triturated with EtOAc, filtered and dried to give 7-(4-hydroxyphenoxy)-2H-1,4-benzoxazin-3(4H)-one as a biege solid (85 mg), Melting point 250-251° C.

Provenance & Evidence