HRID965612

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID111923

Propylphosphonic anhydride

C9H21O6P3

结构：CC(C)(C)OC(=O)NC(C)(C)C(=O)NC(COCc1ccccc1)C(=O)O

HCID12967000

未命名化合物

结构：CC(C)(C)OC(=O)N1CCN2C(=O)N(CC(F)(F)F)C(=O)[C@]2(Cc2ccccn2)C1

HCID57182993

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)NC(C)(C)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCN2C(=O)N(CC(F)(F)F)C(=O)[C@]2(Cc2ccccn2)C1

HCID11411374

未命名化合物

PROCEDURE

实验过程

reacting said 1,3-dioxo-8a(S)-pyridin-2-ylmethyl-2-(2,2,2-trifluoro-ethyl)-hexahydro-imidazo[1,5-a]pyrazine-7-carboxylic acid tert-butyl ester with 3-benzyloxy-2-(2-tert-butoxycarbonylamino-2-methyl-propionylamino)-propionic acid in the presence of a tertiary amine and 1-propanephosphonic acid cyclic anhydride in a reaction inert solvent to form (1-(1(R)-benzyloxymethyl-2-(1,3-dioxo-8a(S)-pyridin-2-ylmethyl-2-(2,2,2-trifluoro-ethyl)-hexahydro-imidazo[1,5-a]pyrazin-7-yl)-2-oxo-ethylcarbamoyl)-1-methyl-ethyl)-carbamic acid tert-butyl ester, and

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-90f45d67231042f3994f5c1de68655de
来源数据集: uspto-grants-2005_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06951850B2
来源说明: uspto-grants-2005_10

反应 SMILES

C(O[C:6]([N:8]1[CH2:13][CH2:12][N:11]2[C:14](=[O:23])[N:15]([CH2:18][C:19]([F:22])([F:21])[F:20])[C:16](=[O:17])[C@:10]2([CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][N:26]=2)[CH2:9]1)=[O:7])(C)(C)C.[CH2:31]([O:38][CH2:39][CH:40]([NH:44][C:45](=[O:57])[C:46]([NH:49][C:50]([O:52][C:53]([CH3:56])([CH3:55])[CH3:54])=[O:51])([CH3:48])[CH3:47])C(O)=O)[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1.CCCP1(OP(CCC)(=O)OP(CCC)(=O)O1)=O>>[C:53]([O:52][C:50](=[O:51])[NH:49][C:46]([C:45](=[O:57])[NH:44][C@H:40]([CH2:39][O:38][CH2:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)[C:6]([N:8]1[CH2:13][CH2:12][N:11]2[C:14](=[O:23])[N:15]([CH2:18][C:19]([F:20])([F:21])[F:22])[C:16](=[O:17])[C@:10]2([CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][N:26]=2)[CH2:9]1)=[O:7])([CH3:48])[CH3:47])([CH3:54])([CH3:55])[CH3:56]