Pentylamine → HCID 12043757, compound

HRID 965656Notes

Reaction equation

HRID 965656 reaction equation
[CH2:1]([C:5]1[C:6](Cl)=[N:7][C:8]([NH2:12])=[N:9][C:10]=1[CH3:11])[CH2:2][CH2:3][CH3:4].[CH2:14]([NH2:19])[CH2:15][CH2:16][CH2:17][CH3:18]>>[NH2:12][C:8]1[N:7]=[C:6]([NH:19][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[C:5]([CH2:1][CH2:2][CH2:3][CH3:4])=[C:10]([CH3:11])[N:9]=1

Participants

3

Reactant 2

HCID 8060PentylamineHCID 27531785-Butyl-4-chloro-6-methylpyrimidin-2-amine

Product 1

HCID 12043757HCID 12043757, compoundYield 78%

Procedure

A mixture of 5-butyl-4-chloro-6-methylpyrimidine-2-yl amine (100 mg, 0.5 mmol) and amylamine (2 ml) was refluxed for 11 hours. The reaction mixture was cooled and the solvent was removed in vacuo and the residue was purified by silica gel column chromatography (MeOH:CHCl3=1:20) to give the object compound (98 mg, 78%) as an oil.

Workup

  1. temperaturewas refluxed for 11 hours
  2. temperatureThe reaction mixture was cooled
  3. customthe solvent was removed in vacuo
  4. customthe residue was purified by silica gel column chromatography (MeOH:CHCl3=1:20)

Sources & evidence

ORD record
ord-3534cda4573c4599b39c508d03acd14c
Source dataset
uspto-grants-2005_10
Patent number
US06951866B2

Reaction notes

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