Pentylamine → HCID 12043758, compound

HRID 965657Notes

Reaction equation

HRID 965657 reaction equation
Cl[C:2]1[C:7]([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13])=[C:6]([CH3:14])[N:5]=[C:4]([NH2:15])[N:3]=1.[CH2:16]([NH2:21])[CH2:17][CH2:18][CH2:19][CH3:20]>>[NH2:15][C:4]1[N:3]=[C:2]([NH:21][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])[C:7]([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13])=[C:6]([CH3:14])[N:5]=1

Participants

3

Reactant 2

HCID 8060PentylamineHCID 22313243HCID 22313243, compound

Product 1

HCID 12043758HCID 12043758, compoundYield 87%

Procedure

A mixture of 4-chloro-5-hexyl-6-methylpyrimidine-2-ylamine (1.00 mg, 0.44 mmol) and amylamine (2 ml) was refluxed for 11 hours. The reaction mixture was cooled and the solvent was removed in vacuo. The residue was purified by silica gel column chromatography (MeOH:CHCl3=1:20) to give the object compound (107 mg, 87%) as an oil.

Workup

  1. temperaturewas refluxed for 11 hours
  2. temperatureThe reaction mixture was cooled
  3. customthe solvent was removed in vacuo
  4. customThe residue was purified by silica gel column chromatography (MeOH:CHCl3=1:20)

Sources & evidence

ORD record
ord-bc1384ef394b4ff8814475df66026012
Source dataset
uspto-grants-2005_10
Patent number
US06951866B2

Reaction notes

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