Pentylamine → HCID 22313246, compound

HRID 965662Notes

Reaction equation

HRID 965662 reaction equation
[NH2:1][C:2]1[N:7]=[C:6](Cl)[C:5]([CH2:9][CH2:10][C:11]#[N:12])=[C:4]([CH3:13])[N:3]=1.[CH2:14]([NH2:19])[CH2:15][CH2:16][CH2:17][CH3:18]>O1CCOCC1>[NH2:1][C:2]1[N:3]=[C:4]([CH3:13])[C:5]([CH2:9][CH2:10][C:11]#[N:12])=[C:6]([NH:19][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[N:7]=1

Participants

4

Reactant 2

HCID 8060PentylamineHCID 21813589HCID 21813589, compound

Product 1

HCID 22313246HCID 22313246, compoundYield 55%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of 3-(2-amino-4-chloro-6-methylpyrimidine-5-yl)propanenitrile (500 mg, 2.54 mmol), amylamine (2.94 ml) and dioxane (5 ml) was kept at 90° C. for 8.5 hours. The procedure according to pro-treatment of Example 23 was carried out to give the object compound (346 mg, 55.0%).

Sources & evidence

ORD record
ord-c11129df3d3b4e45b06ec09b9edf943f
Source dataset
uspto-grants-2005_10
Patent number
US06951866B2

Reaction notes

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