Phosphorus oxychloride → HCID 2753178、化合物

HRID 965670ノート

反応式

HRID 965670 の反応式
[NH2:1][C:2]1[N:7]=[C:6](O)[C:5]([CH2:9][CH2:10][CH2:11][CH3:12])=[C:4]([CH3:13])[N:3]=1.P(Cl)(Cl)([Cl:16])=O>>[CH2:9]([C:5]1[C:6]([Cl:16])=[N:7][C:2]([NH2:1])=[N:3][C:4]=1[CH3:13])[CH2:10][CH2:11][CH3:12]

参加物

3

反応物 2

HCID 24813Phosphorus oxychlorideHCID 178441161HCID 178441161、化合物

生成物 1

HCID 2753178HCID 2753178、化合物収率 29%

実験手順

2-Amino-5-butyl-6-methylpyrimidine-4-ol (1.0 g, 5.52 mmol) and phosphorus oxychloride (12 ml) were refluxed for 3 hours. The solvent was removed in vacuo and the residue was purified by silica gel column chromatography(n-hexane:ethyl acetate=2:1) to give the object compound (325 mg, 29%).

後処理

  1. customThe solvent was removed in vacuo
  2. customthe residue was purified by silica gel column chromatography(n-hexane:ethyl acetate=2:1)

出典と根拠

ORDレコード
ord-c12185988a394a608d5db47aaa1e2a68
出典データセット
uspto-grants-2005_10
特許番号
US06951866B2

反応ノート

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