Carbonic acid-guanidine (1:1) → HCID 178494790, compound

HRID 965674Notes

Reaction equation

HRID 965674 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][CH:5]([C:11](=O)[CH3:12])[C:6](OCC)=[O:7].C(=O)(O)O.[NH2:18][C:19]([NH2:21])=[NH:20]>C(O)C>[NH2:21][C:19]1[N:20]=[C:6]([OH:7])[C:5]([CH2:4][CH2:3][O:2][CH3:1])=[C:11]([CH3:12])[N:18]=1

Participants

4

Reactant 2

HCID 286947Carbonic acid-guanidine (1:1)HCID 22313244HCID 22313244, compound

Product 1

HCID 178494790HCID 178494790, compoundYield 41.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of ethyl 2-(2-methoxyethyl)-3-oxobutanoate (4 g, 21 mmol), guanidine carbonate (2.27 g, 16.3 mmol) and ethanol (16 ml) was refluxed for 9 hours. After cooling, the precipitate was filtered and washed with water, ethanol and ether in order, to give the object compound (1.24 g, 31.9%).

Workup

  1. temperaturewas refluxed for 9 hours
  2. temperatureAfter cooling
  3. filtrationthe precipitate was filtered
  4. washwashed with water, ethanol and ether in order

Sources & evidence

ORD record
ord-c7635e40e74e40e691cc08084ad2a0cf
Source dataset
uspto-grants-2005_10
Patent number
US06951866B2

Reaction notes

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