Carbonic acid-guanidine (1:1) → HCID 178433375, compound

HRID 965676Notes

Reaction equation

HRID 965676 reaction equation
[C:1]([CH2:3][CH2:4][CH:5]([C:11](=O)[CH3:12])[C:6](OCC)=[O:7])#[N:2].C(=O)(O)O.[NH2:18][C:19]([NH2:21])=[NH:20]>N1C=CC=CC=1>[NH2:21][C:19]1[N:20]=[C:6]([OH:7])[C:5]([CH2:4][CH2:3][C:1]#[N:2])=[C:11]([CH3:12])[N:18]=1

Participants

4

Reactant 2

HCID 286947Carbonic acid-guanidine (1:1)HCID 13328085Ethyl 2-(2-cyanoethyl)-3-oxobutanoate

Product 1

HCID 178433375HCID 178433375, compoundYield 64.5%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A mixture of ethyl 2-(2-cyanoethyl)-3-oxobutanoate (9 g, 49 mmol), guanidine carbonate (5.30 g, 29.4 mmol) and pyridine (49 ml) was kept at 100° C. for 8 hours. The procedure according to pro-treatment of Reference-example 6 was carried out to give the object compound (3.38 g, 38.6%).

Sources & evidence

ORD record
ord-1b61c62c46b544b2b35179100d8f53e3
Source dataset
uspto-grants-2005_10
Patent number
US06951866B2

Reaction notes

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