反应详情

Pd/C (10%, 10 mg) is added to a solution of 6-azido-4-[2-(6-fluoro-pyridin-2-yl)-imidazol-1-ylmethyl]-5-propyl-pyrimidine (2 mmol) in MeOH (20 mL). The mixture is stirred under H2 at 30 psi for 4 hours. The catalyst is filtered away and the filtrate is evaporated in vacuo to give the title compound as a yellow solid. 1H NMR (CDCl3) 8.35 (s, 1H), 8.12-8.14 (m, 1H), 7.82 (t, 1H), 7.17 (d, 1H), 7.13 (d, 1H), 6.80-6.82 (m, 1H), 5.92 (s, 2H), 4.88 (s, 2H), 2.53-2.57 (m, 2H), 1.48-1.55 (m, 2H), 0.95 (t, 3H).

1. filtrationThe catalyst is filtered away
2. customthe filtrate is evaporated in vacuo