反应详情

温度

70 °C

A mixture of 6-chloro-4-[2-(6-fluoro-pyridin-2-yl)-imidazol-1-ylmethyl]-5-propyl-pyrimidine (60 mg, 0.18 mmol) and ethylamine (2M in THF, 2 mL) is heated at 70° C. in a sealed tube overnight. Solvent is removed. Water (10 mL) and ethyl acetate (15 mL) are added. The layers are separated—the aqueous layer is extracted with ethyl acetate (2×20 mL) and the organic layers are combined. On drying, the solvent is removed in vacuo. Preparative TLC separation gives the title compound. LC-MS (M+1) 341.2 (retention time: 1.00 min).

1. customSolvent is removed
2. additionWater (10 mL) and ethyl acetate (15 mL) are added
3. extractionis extracted with ethyl acetate (2×20 mL)
4. customOn drying
5. customthe solvent is removed in vacuo
6. customPreparative TLC separation